About the project:

The project’s main goal is to introduce the treatment for limbal stem cell deficiency (LSCD) into clinical practice. Under experimental conditions, we culture (grow and multiply) limbal epithelial cells obtained from the eye, which will be used to treat unilateral LSCD, and epithelial cells from the oral mucosa, used to treat bilateral LSCD. We prepare and test suitable materials (polylactide nanofibers, fibrin glue) on which the cells grow and the solutions in which we culture them. Additionally, we are developing tests to evaluate the DNA stability of cultured cells and their long-term storage.

Beneficiary and project partners:

Univerzita Karlova
University of Oslo
NILU-Norwegian Institute for Air Research
Ústav makromolekulární chemie AV ČR, v. v. i.
Fakultní nemocnice Královské Vinohrady